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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KIF22 All Species: 20.61
Human Site: S543 Identified Species: 45.33
UniProt: Q14807 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14807 NP_015556.1 665 73262 S543 L I Q E Q A A S P N A E I H I
Chimpanzee Pan troglodytes XP_510910 679 74714 S543 L I Q E Q A A S P N A E I H I
Rhesus Macaque Macaca mulatta XP_001104365 657 72278 S535 L I Q E Q A A S P N A E I H I
Dog Lupus familis XP_547058 651 71817 S529 L I Q E Q A A S P N A E I H I
Cat Felis silvestris
Mouse Mus musculus Q3V300 660 73171 S541 I Q K Q R E S S N Q I Q L L K
Rat Rattus norvegicus Q5I0E8 657 73037 S537 R I Q K Q S E S S N K I H L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q7ZYL5 650 73149 Q532 V L R V L P M Q G N S Q L Q S
Zebra Danio Brachydanio rerio A8WFU8 634 70574 Q510 V S Q V Q P L Q Q C A V V C K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46867 784 88189 S534 E L K K R K L S K C Y A K Y L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P46873 699 78760 W579 W N E D E S R W I L P E M S M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LPC6 894 98404 Q617 S L P S R H S Q A R E S V N G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.1 94.8 90 N.A. 81.3 81 N.A. N.A. N.A. 52.3 50.9 N.A. 29.2 N.A. 28.1 N.A.
Protein Similarity: 100 97.5 96.2 93 N.A. 88.7 88.8 N.A. N.A. N.A. 69.3 66.1 N.A. 46.1 N.A. 45.7 N.A.
P-Site Identity: 100 100 100 100 N.A. 6.6 33.3 N.A. N.A. N.A. 6.6 20 N.A. 6.6 N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 53.3 53.3 N.A. N.A. N.A. 46.6 33.3 N.A. 46.6 N.A. 46.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 37 37 0 10 0 46 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 19 0 0 0 10 0 % C
% Asp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 10 37 10 10 10 0 0 0 10 46 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 10 % G
% His: 0 0 0 0 0 10 0 0 0 0 0 0 10 37 0 % H
% Ile: 10 46 0 0 0 0 0 0 10 0 10 10 37 0 37 % I
% Lys: 0 0 19 19 0 10 0 0 10 0 10 0 10 0 19 % K
% Leu: 37 28 0 0 10 0 19 0 0 10 0 0 19 19 19 % L
% Met: 0 0 0 0 0 0 10 0 0 0 0 0 10 0 10 % M
% Asn: 0 10 0 0 0 0 0 0 10 55 0 0 0 10 0 % N
% Pro: 0 0 10 0 0 19 0 0 37 0 10 0 0 0 0 % P
% Gln: 0 10 55 10 55 0 0 28 10 10 0 19 0 10 0 % Q
% Arg: 10 0 10 0 28 0 10 0 0 10 0 0 0 0 0 % R
% Ser: 10 10 0 10 0 19 19 64 10 0 10 10 0 10 10 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 19 0 0 19 0 0 0 0 0 0 0 10 19 0 0 % V
% Trp: 10 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _